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. 1998 Aug 1;112(2):181–197. doi: 10.1085/jgp.112.2.181

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Channel block by ACh does not influence AChR desensitization. Each symbol is from one patch (αY93F AChR, −100 mV). (top) Example clusters. (bottom left) The single channel amplitude is reduced at high concentrations because of flickery channel block by the agonist. The equilibrium dissociation constant for ACh block is 1.9 mM. (bottom right) The desensitization rate constant plotted as a function of the fractional occupancy of the pore by the blocker. Channel block by ACh does not influence the desensitization rate constant.

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