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. 1998 Aug 1;112(2):97–111. doi: 10.1085/jgp.112.2.97

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Effect of osmotic cell swelling on ENaC whole-cell currents. Representative example of the effect of a 33% decrease of solution osmolarity. Whole-cell currents were measured as described in materials and methods. As seen in A and B, there were no appreciable changes in the currents between the control 210 mosmol and the hypo-osmotic 140 mosmol solutions. The small increase of current with hypo-osmolarity was accompanied by a similar increase of the amiloride-insensitive current before (C ) and after (D) hypo-osmolarity.