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. 1998 Aug 1;112(2):97–111. doi: 10.1085/jgp.112.2.97

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Effect of mechanical swelling on whole-cell currents in ENaC and water-injected oocytes pretreated with cytochalasin B. Currents in ENaC-expressing oocytes (A) responded to injection of 90 nl of 100-mM KCl with a transient stimulation (10 s, B) that gradually declined toward baseline by 10 min (C ). However, the same pattern of stimulation was observed in water-injected oocytes (D) that exhibited an initial increase (10 s, E ) that declined toward baseline within 10 min (F ). The two examples shown here were chosen to reflect the potential for very large initial stimulation in response to volume injection in both control oocytes and ENaC-expressing oocytes.