Table 2.

Estimated counts (×10⁷) of myeloid, erythroid and lymphoid cells, and the myeloid:erythroid (M:E) ratio in the femoral marrow of control mice, and animals treated with azathioprine (AZA) at 40–120 mg/kg daily, for 10 days and sampled at 1 day after the final dose

	AZA treatment (mg/kg)
	0 (Control)	40	60	80	100	120
Myeloid	2.63 (0.24)	1.74 (0.85)	0.82 (0.38)	0.38* (0.36)	0.13*** (0.10)	0.16** (0.18)
Erythroid	1.71 (0.15)	0.50*** (0.24)	0.30*** (0.13)	0.33*** (0.13)	0.50*** (0.20)	0.42*** (0.18)
Lymphoid	1.34 (0.27)	0.57 (0.29)	0.33 (0.16)	0.17* (0.03)	0.08*** (0.03)	0.13** (0.11)
Other	0.21 (0.05)	0.16 (0.11)	0.09 (0.03)	0.07 (0.03)	0.05** (0.03)	0.05* (0.02)
M:E ratio	1.54 (0.15)	3.88 (2.17)	2.87 (1.43)	1.24 (0.98)	0.24 (0.13)	0.42 (0.50)

Two hundred cells in the tibial marrow smears were differentially counted by eye and the absolute number of cells of each lineage was estimated for the nucleated marrow cell count of the femoral marrow flush. Values are means, SD in parenthesis; n = 6 randomly selected animals per group. Cells categorized as ‘other’ include monocytes and monocyte precursors, mast cells, megakaryocyes, plasma cells and unidentifiable cells. Data analysed using a one-way analysis of variance (anova).

^*Significantly different from controls, P < 0.05;

^**P < 0.01;

^***P < 0.001.