Table 3.
Apoptosis in the femoral bone marrow of female CD-1 mice treated with 10 daily doses of azathioprine (AZA) at 0 (vehicle control), 40, 60, 80, 100 and 120 mg/kg and sampled at 1 day after the final dose; the percentages of live, apoptotic, and dead cells, and apoptotic plus dead cells is given, but excluding cell debris
| AZA dose level (mg/kg) | Live cells (%) | Apoptotic cells (%) | Dead cells (%) | Apoptotic + dead cells (%) |
|---|---|---|---|---|
| 0 | 80.75 (4.22) | 10.22 (2.08) | 9.02 (2.47) | 19.25 (4.22) |
| 40 | 76.26 (4.52)** | 9.28 (2.09) | 14.46 (2.93)*** | 23.74 (4.52)** |
| 60 | 76.18 (7.21)* | 7.94 (2.72)* | 15.88 (5.02)*** | 23.82 (7.21)* |
| 80 | 63.15 (14.39)*** | 10.43 (4.59) | 26.43 (11.05)*** | 36.85 (14.39)*** |
| 100 | 56.22 (9.40)*** | 13.38 (2.44)*** | 30.40 (7.75)*** | 43.78 (9.40)*** |
| 120 | 57.73 (3.68)*** | 13.13 (2.11)*** | 29.13 (4.31)*** | 42.27 (3.68)*** |
Values are means, SD in parenthesis; n = 5 per dose level group;
*
significantly different from controls, P < 0.05;
**
P < 0.01;
***
P < 0.001.