. 2008 Apr;89(2):138–158. doi: 10.1111/j.1365-2613.2008.00575.x

Table 4.

Haematological results from female CD-1 mice treated daily with 10 doses of azathioprine (AZA) at 100 mg/kg and sampled at 1–57 days after the final dose

	Day of sampling

	1		3		9		22		29		43		57

	Control	AZA	Control	AZA	Control	AZA	Control	AZA	Control	AZA	Control	AZA	Control	AZA
RBC	7.93 (0.35)	6.48 (0.71)^***	7.97 (0.32)	5.25 (0.68)^***	8.31 (0.45)	1.71 (0.47)^***	8.26 (0.22)	7.17 (0.52)^***	8.55 (0.42)	7.41 (0.38)^***	8.50 (0.34)	8.08 (0.39)^*	8.73 (0.37)	8.22 (0.39)^*
Hb	139.0 (4.7)	112.4 (10.4)^***	140.9 (5.0)	91.0 (12.3)^***	141.6 (4.7)	29.2 (7.6)^***	140.0 (3.9)	136.2 (6.3)	143.0 (6.6)	134.8 (3.0)^**	141.3 (4.2)	141.8 (6.1)	142.7 (6.1)	138.0 (5.3)
HCT	0.47 (0.01)	0.37 (0.04)^***	0.47 (0.02)	0.29 (0.04)^***	0.47 (0.02)	0.09 (0.02)^***	0.46 (0.02)	0.45 (0.02)	0.47 (0.02)	0.45 (0.01)^*	0.47 (0.02)	0.46 (0.02)	0.49 (0.02)	0.47 (0.02)
MCV	59.5 (1.7)	57.0 (1.7)^**	58.6 (1.7)	54.8 (1.0)^***	57.0 (1.7)	51.5 (1.8)^***	56.2 (1.6)	62.3 (2.0)^***	55.5 (2.0)	60.6 (2.8)^***	54.7 (1.3)	56.4 (0.8)^**	55.6 (2.2)	57.4 (1.8)
MCH	17.5 (0.6)	17.4 (0.6)	17.7 (0.6)	17.3 (0.4)	17.1 (0.5)	17.0 (0.2)	16.9 (0.2)	19.0 (1.0)^***	16.8 (0.6)	18.2 (0.7)^***	16.7 (0.4)	17.5 (0.2)^***	16.4 (0.6)	16.8 (0.8)
MCHC	295.3 (5.8)	304.6 (5.8)^**	301.6 (9.4)	315.4 (6.5)^**	299.8 (10.4)	329.6 (7.5)^**	301.1 (6.4)	305.0 (6.6)	302.0 (6.3)	300.4 (3.7)	304.5 (5.9)	311.2 (4.9)^*	294.3 (6.9)	292.4 (7.2)
Retic	292 (80)	0.98 (0.4)^***	249 (67)	0.91 (0.6)^***	354 (91)	1.26 (0.4)^***	319 (138)	166 (39)^**	282 (95)	275 (98)	234 (70)	315 (171)	274 (98)	249 (95)
Plt	1440 (242)	133 (103)^***	1496 (268)	57 (61)^***	1477 (175)	9 (2)^***	1338 (156)	930 (220)^***	1407 (134)	1171 (161)^**	1439 (139)	1220 (155)^**	1445 (171)	1366 (190)
WBC	0.82 (0.29)	0.47 (0.16)^**	1.49 (0.54)	0.32 (0.14)^***	1.09 (0.57)	0.24 (0.11)^***	1.20 (0.34)	1.37 (0.39)	1.07 (0.34)	1.29 (0.29)	0.93 (0.34)	2.20 (1.29)^**	1.47 (0.56)	1.54 (0.68)
Neut	0.13 (0.06)	0.00 (0.01)^***	0.34 (0.12)	0.00 (0.01)^***	0.19 (0.10)	0.00 (0.01)^***	0.18 (0.07)	0.31 (0.10)^**	0.19 (0.06)	0.34 (0.19)^*	0.23 (0.13)	0.49 (1.84)^**	0.24 (0.09)	0.28 (0.13)
Lymph	0.59 (0.19)	0.45 (0.15)	1.04 (0.43)	0.30 (0.13)^***	0.82 (0.44)	0.22 (0.10)^**	0.91 (0.30)	0.94 (0.29)	0.82 (0.28)	0.85 (0.13)	0.62 (0.20)	1.57 (1.17)^*	1.10 (0.48)	1.09 (0.54)
Mono	0.01 (0.01)	0.00 (0.00)^***	0.03 (0.01)	0.00 (0.00)^***	0.02 (0.02)	0.00 (0.00)^*	0.02 (0.01)	0.03 (0.02)	0.02 (0.01)	0.03 (0.01)^*	0.01 (0.01)	0.03 (0.02)^*	0.02 (0.01)	0.02 (0.01)
Eo	0.07 (0.06)	0.01 (0.00)^**	0.07 (0.03)	0.01 (0.01)^***	0.05 (0.02)	0.00 (0.01)^***	0.06 (0.02)	0.07 (0.04)	0.07 (0.02)	0.06 (0.01)	0.04 (0.01)	0.04 (0.02)	0.09 (0.02)	0.13 (0.09)
Baso	0.01 (0.00)	0.00 (0.00)	0.01 (0.01)	0.00 (0.00)^*	0.00 (0.01)	0.00 (0.00)	0.00 (0.00)	0.00 (0.01)	0.00 (0.00)	0.00 (0.00)^*	0.00 (0.01)	0.00 (0.00)	0.01 (0.01)	0.00 (0.00)
FNCC	4.27 (0.52)	0.67 (0.21)^***	3.99 (0.51)	0.58 (0.21)^***	3.96 (0.75)	1.56 (1.86)^**	4.07 (0.58)	3.18 (0.60)^**	4.11 (0.73)	3.86 (0.33)	3.75 (0.50)	3.11 (0.49)^*	4.12 (0.63)	4.15 (1.04)

Values are means, SD in parentheses; n = 8 control and AZA-treated mice on days 1 and 3, n = 10 (control) and 5 (AZA) at all other time points, except at day 9, where n = 8 (control) and 5 (AZA), and day 57 where n = 11 (control) and 5 (AZA). Data analysed using Student’s t-test.

Significantly different from controls, P < 0.05;

^**

P < 0.01;

^***

P < 0.001.

Abbreviations and units: see Table 1.