Figure 2.

Significantly higher numbers of phosphorylation at sites Ser^199/202-Thr²⁰⁵ (AT8) immunoreactive NFTs were found in Alzheimer’s disease (AD) brains corresponding to Braak’s staging III–V. Paraffin embedded brain sections from CPLL cases were studied by inmunohistochemistry with Tau-C3 (cleavage at site D⁴²¹) and AT8 and analysed under bright field. Significant differences (*) between the density of neurofibrillary tangles (NFTs) with AT8 and Tau-C3 were found (P = 0.006 in Braak III; P = 0.002 in Braak IV; P = 0.012 in Braak V respectively).