Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Maturation of Neurofibrillary tangles during Alzheimer’s disease (AD) pathology follows a well defined pattern of phosphorylation in several sites such as Ser199, 202, 396, 404, 422, Thr205 and second repeat domain, followed by cleavage of tau at D421 during early stages. According to our data, the pathological process of tau protein during AD could follow two pathways; (a) phosphorylation, conformational change and cleavage, or (b) phosphorylation, cleavage and conformational change.
