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Reticulin staining (magnification ×10). No fibrosis is observed in sham-operated mice (a) and PPVL mice (c). Marked portal-to-portal fibrotic septa and nodule formation (black arrows) are observed in CBDL mice after 6 weeks of induction (b). Sixteen weeks of CCl4 administration induces central-portal fibrotic alterations (black arrow) (d). PPVL, partial portal vein ligation; CBDL, common bile duct ligation; CCl4, carbon tetrachloride.
