Table 1.
Macroscopic and laboratory features of all experimental groups: partial portal vein ligation
| Sham-operated 14 days (n = 4) | PPVL 2 days (n = 6) | PPVL 5 days (n = 6) | PPVL 7 days (n = 6) | PPVL 14 days (n = 6) | |
|---|---|---|---|---|---|
| Liver weight (g/10 g BW) | 0.37 ± 0.04 | 0.43 ± 0.02 | 0.48 ± 0.02 | 0.47 ± 0.03 | 0.41 ± 0.01 |
| Spleen weight (g/10 g BW) | 0.030 ± 0.002 | 0.028 ± 0.002 | 0.050 ± 0.005*† | 0.065 ± 0.009*† | 0.066 ± 0.005*† |
| AST (IU/l) | 43 ± 10 | 36 ± 9 | 29 ± 6 | 34 ± 5 | 38 ± 4 |
| ALT (IU/l) | 4 ± 1 | 3 ± 1 | 4 ± 0.1 | 3 ± 1 | 4 ± 0.1 |
| Bilirubin (mg/dl) | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 |
Values given are mean ± SEM. PPVL, partial portal vein ligation; BW, body weight; AST, aspartate aminotransferase; ALT, alanine aminotransferase.
*
P < 0.05 vs. sham-operated.
†
P < 0.05 vs. PPVL 2d.