Table 2.
Reduction in the gene expression in perifosine treated PC-3 and LNCaP cells with down-regulated GSK-3β or CREB proteins
| Gene | GSKi (perifosine) | CREBi (perifosine) | ||
|---|---|---|---|---|
| % reduction | % reduction | |||
| PC-3 | LNCaP | PC-3 | LNCaP | |
| AZGP | 70 ± 6 | 60 ± 1 | ||
| CEACAM5 | 50 ± 5 | 44 ± 1 | ||
| COX-2 | 65 ± 2 | |||
| GDF15 | 79 ± 2 | 51 ± 10 | 60 ± 8 | |
| ITGB4 | 58 ± 3 | |||
| KRT15 | 62 ± 2 | |||
| KRT19 | 52 ± 3 | |||
| KRT4 | 73 ± 5 | 82 ± 2 | 84 ± 2 | |
| KRT6irs4 | 80 ± 5 | 75 ± 1 | 70 ± 2 | |
| MIG6 | 70 ± 1 | |||
| NDRG1 | 51 ± 7 | |||
| S100P | 84 ± 1 | 57 ± 9 | 48 ± 3 | 60 ± 5 |
| TNFAIP2 | 54 ± 2 | |||