Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Sep 12;4(9):e1000186. doi: 10.1371/journal.pgen.1000186

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Holloway et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A, B) MLH1 focus numbers are increased in Mus81^−/− spermatocytes compared with WT. A) Chromosome spreads from WT (left panel) and Mus81^−/− (right panel) spermatocyte stained with antibodies against SYCP3 (red), MLH1 (green) and CREST autoimmune serum (blue). White arrows show the positions of MLH1 foci for clarity. B) Average MLH1 focus numbers counted in mid pachynema (MP) and late pachynema (LP). Statistically significant increases in Mus81^−/− counts (white) compared with WT (black) are shown by the asterisks. C) Interference is reduced in the mutant (blue) compared to the WT (red). D, E) Chiasmata counts on cells at diakinesis of prophase I for WT (left) and Mus81^−/− (right) mice, chiasmata numbers for each cell are shown, as well as average counts for WT and Mus81^−/−.