Rats were administered vector to their submandibular glands. 3 days later serum and saliva were collected and hEpo immunreactive products measured as described in Materials and Methods. Animals transduced with AdCMVhEpo-hGH, or AdCMVhGH-hEpo had statistically higher saliva/saliva plus serum ratios of immunoreactive hEpo products when compared to those found in animals transduced with AdCMVhEpo (p<0.0001 and p=0.0083, respectively), i.e. relatively higher levels of immunoreactive hEpo were being secreted into saliva. For these analyses, the number of rats tested was for hEpo (n=23), for hEpo-hGH (n=24), and for hGH-hEpo (n=9). The horizontal bar represents the median value.