Figure 1.
Increased h-current with altered kinetics in CA1 pyramidal apical dendrites following HT. (A) Dendritic cell-attached recordings of Ih at a 200 μm distance from the soma. Hyperpolarizing, 1500 ms long voltage commands from a holding potential 20 mV depolarized from rest produced slowly activating, non-inactivating inward currents characteristic of the h-current in control (left) and HT (right) dendrites. (B) Peak inward currents in control (open squares) and HT (filled circles) dendrites. (C) Tail currents from control (open squares) and HT (filled circles) dendrites. (D) Fitted activation (control, open squares; HT, filled circles) and deactivation (control, open diamonds; HT, filled triangles) time constants for the h-current. (E) Boltzmann activation curves for Ih fitted to normalized tail currents from control (open squares) and HT (filled circles) dendrites. (F) Half activation potential for Ih from control (open bar) and HT (filled bar) dendrites.