Figure 3.

Altered h-current causes hyperexcitability in three detailed CA1 pyramidal neuron models. (Ai, Bi, Ci) Example traces of response to 1500 ms simulated apical dendritic current injections with control (left) and HT (right) h-current parameters. Note that HT models always fire at lower current injection amplitudes than controls. (Aii, Bii, Cii) Number of action potentials fired in response to 1500 ms simulated dendritic current injections in control (dashed line) and HT (solid line) model cells, from their respective RMPs. (Aiii, Biii, Ciii) Number of action potentials fired in response to 1500 ms simulated apical dendritic current injections in control (dashed line) and HT (solid line) model cells, from a common holding potential. Note that due to specific model parameters, the common holding potential varied between models.