Figure 5.

See-saw partners of peripheral myelin protein (Pmp22) in control spinal cord and alteration by AT-EAE. (A and D) Immune response partners. (B and E) Platelet derived growth factors. (C and F) Calcium signaling genes. The correlation coefficients of the indicated genes with each other gene were plotted against those of Pmp22 with each other gene. In controls, red color indicates likeness, green neutrality, and blue opposition. The table presents the overlap (OVL) of the coordination profiles in both conditions. Note that the AT-EAE turned the significant similarity and opposition of the coordination profiles into neutrality. Cklfsf3, chemokine-like factor super family 3; Ifitm3, interferon-induced transmembrane protein 3; Ier3, immediate early response 3; Pdgfra, platelet derived growth factor receptor, alpha polypeptide; Pdfrl, platelet-derived growth factor, receptor-like; Pdgfc, platelet-derived growth factor, C polypeptide; Itpr1, inositol 1,4,5-triphosphate receptor 1; Grinl1a, glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A; P2rx3, purinergic receptor P2X, ligand-gated ion channel, 3. The overlap scores (OVL) of the Pmp22 in the two conditions were:

Partner	Cklfsf3	Ifitm3	Ier3	Pdgfra	Pdfrl	Pdgfc	Itpr1	Grinl1a	P2rx3
Control	98.51	−93.57	−4.56	93.23	−81.12	3.94	92.30	−95.59	−0.86
AT-EAE	15.54	21.44	16.34	−12.17	2.72	−15.15	−6.09	37.86	0.50