Table 1.
Regulation of immune response genes in AT-EAE spinal cord.
| Name | Symbol | X | p |
|---|---|---|---|
| Histocompatibility 2, class II antigen A, alpha | H2-Aa | 26.37 | 0.000 |
| Complement component 1, q subcomponent, alpha polypeptide | C1qa | 10.03 | 0.000 |
| Guanylate nucleotide-binding protein 2 | Gbp2 | 9.10 | 0.000 |
| Complement component 1, q subcomponent, beta polypeptide | C1qb | 8.45 | 0.000 |
| Proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional protease 2) | Psmb9 | 8.33 | 0.000 |
| Histocompatibility 2, class II antigen A, beta 1 | H2-Ab1 | 6.67 | 0.000 |
| Histocompatibility 2, L region | H2-L | 6.50 | 0.000 |
| Histocompatibility 2, K region | H2-K | 6.33 | 0.000 |
| Macrophage expressed gene 1 | Mpeg1 | 6.08 | 0.000 |
| Fc receptor, IgG, low affinity III | Fcgr3 | 5.52 | 0.001 |
| Histocompatibility 2, D region locus 1 | H2-D1 | 5.30 | 0.001 |
| Chemokine (C–C motif) ligand 9 | Ccl9 | 5.26 | 0.001 |
| Interferon-induced transmembrane protein 3 | Ifitm3 | 4.46 | 0.001 |
| B lymphoma Mo-MLV insertion region 1 | Bmi1 | 4.37 | 0.001 |
| Complement component 3 | C3 | 4.33 | 0.005 |
| Interferon-induced transmembrane protein 1 | Ifitm1 | 4.23 | 0.000 |
| Histocompatibility 2, class II, locus DMa | H2-DMa | 4.22 | 0.001 |
| Interleukin 2 receptor, gamma chain | Il2rg | 3.55 | 0.007 |
| Tumor necrosis factor, alpha-induced protein 2 | Tnfaip2 | 3.53 | 0.000 |
| T-cell receptor alpha, variable 22.1 | Tcra-V22.1 | 3.51 | 0.000 |
| CD44 antigen | Cd44 | 3.24 | 0.000 |
| Proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional protease 7) | Psmb8 | 3.24 | 0.001 |
| LPS-responsive beige-like anchor | Lrba | 3.22 | 0.002 |
| SAM domain and HD domain, 1 | Samhd1 | 3.04 | 0.000 |
| Interferon regulatory factor 1 | Irf1 | 3.04 | 0.000 |
| Interleukin 7 receptor | Il7r | 3.03 | 0.001 |
| Interferon consensus sequence-binding protein 1 | Icsbp1 | 3.01 | 0.000 |
| B-cell leukemia/lymphoma 2-related protein A1d | Bcl2a1d | 2.99 | 0.000 |
| Complement component factor h | Cfh | 2.91 | 0.002 |
| Interleukin 1 family, member 6 | Il1f6 | 2.83 | 0.003 |
| Interferon activated gene 203 | Ifi203 | 2.79 | 0.001 |
| 2′-5′-Oligoadenylate synthetase-like 2 | Oasl2 | 2.71 | 0.006 |
| SLAM family member 8 | Slamf8 | 2.66 | 0.000 |
| Fc receptor, IgE, high affinity I, gamma polypeptide | Fcer1g | 2.63 | 0.005 |
| Immunoglobulin superfamily, member 7 | Igsf7 | 2.61 | 0.004 |
| Interferon-induced transmembrane protein 3-like | Ifitm3l | 2.56 | 0.000 |
| Immediate early response 3 | Ier3 | 2.55 | 0.027 |
| Chemokine (C–C motif) ligand 22 | Ccl22 | 2.46 | 0.012 |
| Histocompatibility 2, Q region locus 7 | H2-Q7 | 2.44 | 0.004 |
| Histocompatibility 2, complement component factor B | H2-Bf | 2.44 | 0.000 |
| Small chemokine (C–C motif) ligand 11 | Ccl11 | 2.41 | 0.000 |
| IL2-inducible T-cell kinase | Itk | 2.39 | 0.000 |
| Histocompatibility 13 | H13 | 2.38 | 0.024 |
| Interferon regulatory factor 6 | Irf6 | 2.30 | 0.001 |
| Proteasome (prosome, macropain) 28 subunit, alpha | Psme1 | 2.27 | 0.003 |
| CD47 antigen (Rh-related antigen, integrin-associated signal transducer) | Cd47 | 2.22 | 0.000 |
| Chemokine-like factor super family 3 | Cklfsf3 | 2.17 | 0.002 |
| Interleukin 11 receptor, alpha chain 1 | Il11ra1 | 2.17 | 0.000 |
| ICOS ligand | Icosl | 2.07 | 0.000 |
| T-complex-associated testis expressed 3 | Tcte3 | 2.07 | 0.000 |
| CD1d1 antigen | Cd1d1 | 2.01 | 0.001 |
| Chemokine (C motif) ligand 1 | Xcl1 | 2.00 | 0.006 |
| Histocompatibility 2, class II antigen E beta | H2-Eb1 | 1.78 | 0.042 |
| Ia-associated invariant chain | Ii | 1.76 | 0.023 |
| Immunoglobulin superfamily, member 8 | Igsf8 | −2.20 | 0.000 |
| Integrin alpha FG-GAP repeat containing 1 | Itfg1 | −2.28 | 0.000 |
X, expression ratio (negative for down-regulation) in AT-EAE with respect to control; p, p-value.