Table 4.
Examples of genes with high (H) and low (L) percentages of synergistic (SYN), antagonistic (ANT), and independent (IND) expression partners within the control (C) spinal cord and the corresponding values for AT-EAE (E) mice.
| Type | Name | Symbol | CHR | FUNC | SYN-C | ANT-C | IND-C | SYN-E | ANT-E | IND-E |
|---|---|---|---|---|---|---|---|---|---|---|
| H-SYN | A disintegrin and metalloprotease domain 10 | Adam10 | 9 | JAE | 28.02 | 16.76 | 3.18 | 16.79 | 16.55 | 4.53 |
| H-SYN | Hermansky–Pudlak syndrome 1 homolog (human) | Hps1 | 19 | TWC | 27.97 | 16.87 | 3.31 | 18.99 | 18.64 | 4.10 |
| H-SYN | Myotubularin-related protein 1 | Mtmr1 | X | CYT | 27.97 | 17.19 | 3.39 | 5.46 | 1.48 | 8.10 |
| H-SYN | Potassium channel tetramerisation domain containing 2 | Kctd2 | 11 | TIC | 27.97 | 17.08 | 3.50 | 8.05 | 4.18 | 5.88 |
| H-SYN | Bromodomain containing 3 | Brd3 | 2 | TRA | 27.94 | 16.66 | 3.39 | 4.77 | 2.01 | 14.14 |
| H-SYN | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | Cad-pendin | 5 | ENE | 27.94 | 16.98 | 3.39 | 17.51 | 18.30 | 3.84 |
| H-SYN | CBF1 interacting corepressor | Cir-pending | 2 | TRA | 27.94 | 16.90 | 3.44 | 14.30 | 10.99 | 4.69 |
| H-SYN | Enoyl-coenzyme A hydratase, short chain, 1, mitochondrial | Echs1 | 7 | ENE | 27.94 | 16.74 | 3.20 | 23.28 | 15.04 | 4.08 |
| H-SYN | Nuclear receptor subfamily 3, group C, member 1 | Nr3c1 | 18 | CSD | 27.94 | 16.60 | 3.26 | 23.54 | 16.53 | 4.10 |
| H-SYN | Nuclear receptor coactivator 1 | Ncoa1 | 12 | CSD | 27.91 | 17.16 | 3.42 | 8.08 | 4.90 | 4.74 |
| L-SYN | Glucose phosphate isomerase 1 | Gpi1 | 7 | ENE | 0.85 | 2.38 | 21.82 | 4.40 | 1.43 | 16.37 |
| L-SYN | Exostoses (multiple)-like 3 | Extl3 | 14 | CSD | 0.87 | 2.01 | 16.82 | 14.88 | 23.17 | 4.05 |
| L-SYN | Phosphoglycerate dehydrogenase like 1 | Phgdhl1 | 14 | ENE | 0.87 | 2.75 | 15.89 | 5.99 | 10.51 | 5.16 |
| L-SYN | Cytotoxic T lymphocyte-associated protein 2 beta | Ctla2b | 12 | JAE | 0.90 | 1.67 | 25.85 | 19.12 | 14.22 | 3.55 |
| L-SYN | HLA-B-associated transcript 8 | Bat8 | 17 | TRA | 0.90 | 2.38 | 21.64 | 17.51 | 13.06 | 3.60 |
| L-SYN | Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha | Nfkbia | 12 | TRA | 0.90 | 1.69 | 25.50 | 12.39 | 15.39 | 4.37 |
| L-SYN | Phospholipase D3 | Pld3 | 7 | SIG | 0.93 | 2.91 | 16.18 | 15.84 | 16.45 | 4.74 |
| L-SYN | Acetyl-coenzyme A acetyltransferase 1 | Acat1 | 9 | ENE | 0.95 | 2.75 | 12.24 | 20.10 | 17.45 | 3.84 |
| L-SYN | Fucosidase, alpha-L-1, tissue | Fuca | 4 | ENE | 0.95 | 1.88 | 13.45 | 18.96 | 10.30 | 4.45 |
| L-SYN | Glyoxalase 1 | Glo1 | 17 | ENE | 0.95 | 2.78 | 11.81 | 12.98 | 21.66 | 4.16 |
| H-ANT | Spastic paraplegia 7 homolog (human) | Spg7 | 8 | UNK | 17.27 | 28.05 | 3.50 | 14.80 | 23.09 | 4.00 |
| H-ANT | Protein tyrosine phosphatase, non-receptor type 9 | Ptpn9 | 9 | SIG | 17.13 | 28.02 | 3.42 | 1.14 | 3.87 | 16.58 |
| H-ANT | Dehydrogenase/reductase (SDR family) member 1 | Dhrs1 | 14 | ENE | 16.95 | 27.99 | 3.58 | 3.95 | 8.58 | 6.09 |
| H-ANT | Kinesin family member 23 | Kif23 | 9 | TWC | 16.84 | 27.97 | 3.31 | 16.63 | 17.32 | 4.18 |
| H-ANT | RNA and export factor-binding protein 2 | Refbp2 | 1 | TRA | 16.92 | 27.97 | 3.34 | 16.74 | 22.70 | 3.65 |
| H-ANT | ADP-ribosylation factor 1 | Arf1 | 11 | TWC | 16.31 | 27.94 | 3.23 | 17.06 | 23.97 | 3.73 |
| H-ANT | Fibroblast growth factor (acidic) intracellular-binding protein | Fibp | 19 | CSD | 17.16 | 27.91 | 3.50 | 2.78 | 2.07 | 6.41 |
| H-ANT | HECT domain containing 1 | Hectd1 | 12 | UNK | 17.06 | 27.91 | 3.47 | 2.91 | 4.48 | 7.42 |
| H-ANT | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | Atp5c1 | 2 | TWC | 17.32 | 27.89 | 3.44 | 16.95 | 18.03 | 4.58 |
| H-ANT | Nuclear RNA export factor 1 homolog (S. cerevisiae) | Nxf1 | 19 | TWC | 17.27 | 27.89 | 3.55 | 5.61 | 3.63 | 7.63 |
| L-ANT | B-cell receptor-associated protein 29 | Bcap29 | 12 | TWC | 2.28 | 0.85 | 19.94 | 22.83 | 13.98 | 4.32 |
| L-ANT | Neighbor of Punc E11 | Nope | 9 | TIC | 2.22 | 0.85 | 20.15 | 7.42 | 5.80 | 4.95 |
| L-ANT | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Rela | 19 | TRA | 1.83 | 0.85 | 17.88 | 23.73 | 16.84 | 4.03 |
| L-ANT | Fat-specific gene 27 | Fsp27 | 6 | CSD | 2.41 | 0.87 | 14.43 | 19.92 | 10.81 | 4.21 |
| L-ANT | Ligand of numb-protein X 2 | Lnx2 | 5 | SIG | 2.75 | 0.87 | 15.86 | 4.29 | 6.59 | 3.34 |
| L-ANT | ras homolog gene family, member H | Arhh | 5 | SIG | 2.20 | 0.87 | 17.74 | 2.54 | 0.95 | 13.59 |
| L-ANT | CpG-binding protein | Cgbp-pend | 18 | TRA | 1.85 | 0.90 | 23.68 | 18.51 | 19.39 | 4.05 |
| L-ANT | Hydroxyacid oxidase 1, liver | Hao1 | 2 | ENE | 2.30 | 0.90 | 18.96 | 10.17 | 5.72 | 5.72 |
| L-ANT | miRNA containing gene | Mirg | 12 | UNK | 2.04 | 0.90 | 24.36 | 9.24 | 5.88 | 4.74 |
| L-ANT | Sphingosine-1-phosphate phosphatase 1 | Sgpp1 | 12 | ENE | 2.25 | 0.90 | 19.33 | 12.45 | 10.54 | 4.69 |
| H-IND | Anterior gradient 2 (Xenopus laevis) | Agr2 | 12 | UNK | 1.03 | 1.51 | 26.11 | 6.99 | 3.20 | 7.73 |
| H-IND | Argininosuccinate lyase | Asl | 5 | ENE | 1.67 | 0.93 | 25.85 | 7.36 | 4.98 | 6.44 |
| H-IND | Cytotoxic T-lymphocyte-associated protein 2 beta | Ctla2b | 12 | JAE | 0.90 | 1.67 | 25.85 | 19.12 | 14.22 | 3.55 |
| H-IND | ATP-binding cassette, sub-family G (WHITE), member 4 | Abcg4 | 9 | TIC | 1.14 | 1.38 | 25.74 | 6.44 | 10.20 | 5.03 |
| H-IND | Sorting nexin 10 | Snx10 | 6 | TWC | 1.01 | 1.67 | 25.72 | 16.98 | 23.83 | 4.10 |
| H-IND | myc-induced nuclear antigen | Mina | 16 | CSD | 1.75 | 1.03 | 25.48 | 20.34 | 10.91 | 4.16 |
| H-IND | Acetyl-coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-coenzyme A thiolase | Acaa2 | 18 | ENE | 1.35 | 1.30 | 25.32 | 17.64 | 23.57 | 3.76 |
| H-IND | Ena-vasodilator stimulated phosphoprotein | Evl | 12 | SIG | 1.01 | 1.77 | 25.32 | 8.63 | 4.45 | 4.79 |
| H-IND | Solute carrier family 25 (mitochondrial carrier; ornithine transporter), member 15 | Slc25a15 | 8 | TWC | 1.59 | 1.11 | 25.19 | 11.10 | 6.25 | 5.40 |
| H-IND | AE-binding protein 2 | Aebp2 | 6 | TRA | 1.80 | 0.95 | 24.97 | 1.85 | 4.82 | 16.45 |
| L-IND | Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | Anp32e | 3 | UNK | 26.30 | 13.22 | 2.83 | 4.79 | 1.48 | 16.31 |
| L-IND | Fatty acid amide hydrolase | Faah | 4 | ENE | 27.20 | 14.38 | 2.83 | 18.46 | 9.90 | 4.56 |
| L-IND | Meiotic recombination 11 homolog A (S. cerevisiae) | Mre11a | 9 | ENE | 26.24 | 13.11 | 2.83 | 24.02 | 16.98 | 5.48 |
| L-IND | BCL2-associated athanogene 4 | Bag4 | 8 | CSD | 25.98 | 12.95 | 2.89 | 15.76 | 8.18 | 5.08 |
| L-IND | KDEL containing protein 1 | Kdel1 | 1 | TRA | 26.22 | 13.19 | 2.89 | 24.02 | 16.98 | 3.34 |
| L-IND | Nuclear fragile X mental retardation protein interacting protein | Nufip1 | 14 | TWC | 24.55 | 11.57 | 2.89 | 13.16 | 6.81 | 5.22 |
| L-IND | T-box 2 | Tbx2 | 11 | TRA | 26.01 | 12.71 | 2.89 | 19.23 | 20.37 | 3.42 |
| L-IND | Disrupted in bipolar disorder 1 homolog (human) | Dibd1 | 9 | TRA | 27.09 | 14.27 | 2.91 | 9.19 | 5.27 | 5.61 |
| L-IND | Phosphatidylglycerophosphate synthase 1 | Pgs1-pend | 11 | UNK | 14.19 | 27.12 | 2.91 | 1.11 | 2.01 | 7.71 |
| L-IND | Solute carrier family 4, sodium bicarbonate cotransporter, member 7 | Slc4a7 | 14 | TIC | 26.22 | 13.29 | 2.91 | 5.01 | 2.38 | 10.67 |
CHR, chromosome location; FUNC, primary function performed by the encoded protein.