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. Author manuscript; available in PMC: 2008 Aug 27.
Published in final edited form as: Org Lett. 2007 Feb 1;9(3):381–384. doi: 10.1021/ol062264h

Table 2.

Optimization of Ti(O-i-Pr)4 : BINOL Ratio and Catalyst Mol % Under Highly Concentrated Conditions.

graphic file with name nihms61841f4.jpg
entry Ti(O -i-Pr)4 (mol % ) BINOL (mol %) IPA (equiv) %ee (% yield)
1 10 10 3 88 (88)
2 10 20 3 95 (93)
3 5 10 3 90 (90)
4 2 4 3 55 (97)
5 1 2 3 28 (95)