Table 3.
Yields and Enantioselectivities for the Asymmetric Allylation of Ketones Under Highly Concentrated Conditions with 1:2 Ti : BINOL Ratio.
| entry | substrate | Ti:BINOL (mol %) | Sn(allyl)4 (equiv) | IPA (equiv) | % ee (% yield) |
|---|---|---|---|---|---|
| 1 |
|
10:20 | 1.5 | 3 | 95 (93) |
| 2 | 5:10 | 1.5 | 3 | 90 (90) | |
| 3 |
|
10:20 | 1.5 | 3 | 89 (87) |
| 4 | 5:10 | 1.5 | 3 | 79 (85) | |
| 5 |
|
10:20 | 1.5 | 3 | 88 (99) |
| 6 | 5:10 | 1.5 | 3 | 82 (92) | |
| 7 |
|
10:20 | 1.5 | 3 | 91 (96) |
| 8 | 5:10 | 1.5 | 3 | 85 (99) | |
| 9 |
|
10:20 | 1.5 | 3 | 91 (80) |
| 10 | 5:10 | 1.5 | 3 | 86 (85) | |
| 11 |
|
10:20 | 1.5 | 3 | 87 (99) |
| 12 | 5:10 | 1.5 | 3 | 79 (99) |