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. 2008 Sep 1;205(9):1949–1957. doi: 10.1084/jem.20081007

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Copyright © 2008, The Rockefeller University Press

This article is distributed under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — Happloinsufficiency in plasma cell tumor development in AID^+/− mice. (A) Photomicrographs of plasma cell tumors arising in BALB/c-Bcl-xL AID^+/+ and BALB/c-Bcl-xL AID^+/− mice show no significant variations in plasma cell morphology. Bar, 20 μm. (B, left) Incidence of plasma cell tumors in the presence of Bcl-xL as determined by the histological appearance of foci, with each containing 50 or more atypical plasma cells (red squares, plasma cell tumors in 36 out of 41 AID^+/+ mice injected with pristane; black circles, plasma cell tumors in 58 out of 96 AID^+/− mice). (right) Plasmacytoma development in AID^+/+ (n = 16) and AID^+/− (n = 39) mice in the absence of Bcl-xL.