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. 2008 Sep 1;205(9):1949–1957. doi: 10.1084/jem.20081007

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Copyright © 2008, The Rockefeller University Press

This article is distributed under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 3. — Reduced AID activity in AID^+/− mice during the immune response. (A) Measurement of IgG1 levels in GCs from AID^+/+ and AID^+/− mice. Values represent the mean ± SD (n = 5). (B) Somatic hypermutation as determined by sequencing the JH4 intron from AID^+/+, AID^+/−, and AID^−/− GC cells. (C) ELISA analysis of serum from five AID^+/+ and AID^+/− mice immunized with NP-CGG. IgG1 antibodies displaying low affinity for NP were captured in this assay using NP₃₀-BSA, whereas high affinity antibodies were monitored with NP₇-BSA, as described in Results and discussion. Horizontal bars represent the mean.