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. 2008 Sep 1;205(9):2005–2017. doi: 10.1084/jem.20081219

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© 2008 Chong et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Drosha deficiency at the DP thymocyte stage partially perturbs thymocyte output. (A) Total thymocyte and splenocyte numbers in Drosha^F/Δ CD4-cre and Drosha^F/+ CD4-cre (control) mice. (B) TCRβ versus TCRγδ expression on total thymocytes. (C) CD24 and CD69 expression on TCRβ^hi gated thymocytes. (D) CD4 versus CD8 expression on total, postselected (TCRβ^hiCD24^hi/69⁺) and mature (TCRβ^hiCD24^lo/69⁻) thymocytes. (E and F) FACS analysis of populations in total splenocytes (E) and TCRβ⁺ splenocytes (F). Also shown is the effect of Dicer deficiency. Percentages of cells are shown in B–F. (G) Absolute CD4⁺8⁺ DP, mature thymocyte, and TCRβ⁺ splenocyte numbers. (H) CD4/CD8 ratio in the mature thymocyte and TCRβ⁺ splenocyte compartments.