Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Sep 1;205(9):2005–2017. doi: 10.1084/jem.20081219

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Chong et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — T cell–specific Drosha deficiency results in spontaneous inflammatory disease and premature mortality. (A) Kaplan-Meyer survival plot of Drosha^F/Δ CD4-cre and control mice (Drosha^F/F, Drosha^Δ^/+ , or Drosha^F/+ CD4-cre). (B) Aberrant activation of CD4⁺ T cells in lymphoid organs of moribund Drosha^F/Δ CD4-cre mice. (C and D) Cytokine expression by CD4⁺ (C) and CD8⁺ (D) T cells. (E) Frequent IFN-γ and IL-17A coexpression by CD4⁺ T cells. (F) Granulocyte (Gr-1⁺) and γδT cells populations in lymphoid organs. Percentages of cells are shown in B–F. (G) H&E-stained sections of the lung (i and iii) and liver (ii, iv, and v). Bars, 100 μm.