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. 2008 Sep 1;205(9):2005–2017. doi: 10.1084/jem.20081219

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© 2008 Chong et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Drosha deficiency does not prevent polarization of naive CD4⁺ T cells into Th1 or Th2 cells. Naive CD62L^hi44^lo25⁻ CD4⁺ T cells from Drosha^F/Δ CD4-cre and control Drosha^F/+ CD4-cre mice were activated in vitro with anti-CD3/28 antibodies and 10 U/ml IL-2, plus (A) IL-12 and 1 μg/ml anti–IL-4 antibody or (B) IL-4 and 1 μg/ml anti-IFN-γ antibody for 4 d. The anti-CD3/28 antibodies were removed from the culture for the last 24 h, after which the cells were restimulated with PMA/ionomycin for 3 h in the presence of GolgiStop and analyzed for intracellular IFN-γ and IL-4 expression by FACS. Percentages of cells are shown.