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. 2008 Sep 1;205(9):2019–2031. doi: 10.1084/jem.20072689

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© 2008 Déruaz et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Evasin-1 inhibits cell recruitment in vitro and in vivo. (a) Inhibition of CCL3- (▪), CCL3L1- (•) and CCL4-mediated (▴) chemotaxis of L1.2/CCR5 transfectants. The IC₅₀ values are 2 nM for CCL3, 0.17 nM for CCL3L1, and 4 nM for CCL4. Data are shown as the mean ± the SD as a percentage of maximal recruitment and are representative of three to five individual experiments. (b) Evasin-1 inhibits granulocyte recruitment induced by CCL3 in mice. Evasin-1 was administered s.c. 45 min before the injection of 10 μg of CCL3 i.p. Cells in the peritoneal cavity were counted 18 h after the injection of CCL3. One representative experiment of three is shown, with 8 mice per group. **, P < 0.01 when compared with PBS-treated group. Error bars represent the mean ± SEM.