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. 2008 Sep 1;205(9):2019–2031. doi: 10.1084/jem.20072689

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© 2008 Déruaz et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Evasin-1 inhibits lethality, cellular recruitment, and fibrosis in a model of bleomycin-induced pulmonary injury. (a) Evasin-1 inhibits lethality associated with pulmonary instillation of bleomycin in C57BL/6 mice. Bleomycin was instilled intratracheally at doses of 0.0625 U (circles) or 0.125 U (squares) and survival rates were evaluated for 25 d. PBS (open symbols) or Evasin-1 (10 μg per animal; closed symbols) were administered s.c. 45 min before and every 12 h after initial bleomycin instillation. There were 12 mice per group in each experiment. *, P < 0.05 when comparing PBS- and Evasin-1–treated animals at 0.125 U. (b) Evasin-1 inhibits neutrophil recruitment induced by bleomycin. Neutrophil recruitment was evaluated at 2 and 8 d after bleomycin (0.125 U) and Evasin-1 (10 μg per animal) was administered s.c. 45 min before and every 12 h after initial bleomycin instillation. There were six mice per group in each experiment. *, P < 0.05 when compared with the PBS-treated group. Error bars represent the mean ± SEM. (c) Evasin-1 inhibits pulmonary inflammation and fibrosis induced by instillation of bleomycin. Hematoxylin and eosin– (top) and Gomori's trichrome–stained (bottom) sections from animals instilled with sodium chloride (0.9% NaCl, 25 μl) or bleomycin (0.125 U). Evasin-1 (10 μg per animal) was administered as previously described and lungs were removed on day 16. Bars: (top) 100 μm; (bottom) 50 μm.