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. 2008 Sep 1;205(9):2019–2031. doi: 10.1084/jem.20072689

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© 2008 Déruaz et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — Evasin-3 inhibits neutrophil recruitment and ameliorates inflammation and functionality in a mouse model of antigen-induced arthritis. (a–g) Reduction of inflammation in mBSA induced arthritis by Evasin-3 (1 μg per animal). (a) Inhibition of total cell accumulation in the synovial cavity. (b) Inhibition of neutrophil infiltration into the knee joint. (c) Reduction of hypernociception induced by intraarticular antigen challenge of immunized mice. (d) Reduction of TNF-α production in periarticular tissues. (e) Inhibition of adhesion of leukocytes to synovial microvessels as assessed by intravital microscopy. (f and g) Histological evaluation of the tissue sections form the knee joint. All parameters were evaluated 24 h after antigen challenge, and there were 6 mice per group in each experiment. *, P < 0.05; **, P < 0.01. Error bars represent the mean ± SEM. Bars, 100 μm.