Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Sep 1;205(9):2043–2052. doi: 10.1084/jem.20080559

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Carey et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — IgH and IgL selection in TdT^+/+/TdT^−/− chimeric mice. Mice were reconstituted with equal proportions of B220⁻ donor BM TdT^+/+ and TdT^−/− cells. (A) The TdT^+/+/TdT^−/− ratio in BM and spleen B cell compartments of chimeric mice. Data were normalized with respect to the combined Fr. A–D compartment (dotted line; n = 21 mice). Data represent the mean ± SEM. Statistically significant differences are indicated (*, P < 0.05; **, P < 0.01; ***, P < 0.001). (B) IgL usage in BM and spleen B cell compartments of chimeric mice (n = 12–20 mice). Data represent the mean ± SEM. With the exception of the T1 compartment, TdT^−/− cells had significantly higher frequencies of Igλ⁺ cells than TdT^+/+ cells. Statistically significant differences in light chain usage between TdT^+/+ cells in each subset are indicated (*, P < 0.05; ***, P < 0.001), and between TdT^−/− cells, statistical significance is shown (⁺, P < 0.05; ⁺⁺, P < 0.01; ⁺⁺⁺, P < 0.001).