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. 2008 Sep 1;205(9):2111–2124. doi: 10.1084/jem.20072076

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© 2008 Das et al.

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Figure 3. — Intrahepatic CD8 T cells from patients with CHB are biased toward IFN-γ over IL-2 production. (a) Intrahepatic CD8 T cells were isolated from liver biopsies, and cytokine production was determined by intracellular staining after anti-CD3/anti-CD28 stimulation. Representative dot plots show IL-2 and IFN-γ production by CD8 T cells for a typical patient with chronic HBV and a patient with nonviral liver pathology. (b) After mitogenic stimulation, the ratio of IFN-γ/IL-2 production by intrahepatic CD8 T cells was determined for six patients with CHB and six patients without CHB. Ratios are plotted in the histogram shown.

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