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. 2008 Sep 1;205(9):2111–2124. doi: 10.1084/jem.20072076

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© 2008 Das et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Reconstitution of CD3ζ and CD28 levels with a chimeric receptor reverses the IL-2 defect. (a) Histogram shows transfection efficiency in a representative patient after transfection of a chimeric receptor with an extracellular CD33-binding domain and intracellular CD3ζ and CD28 domains. (b) After antigen-specific stimulation through the chimeric receptor, TCR (anti-CD3/anti-CD28), or both together, IL-2 production was determined by ELISA. Mean and SEM of IL-2 production is shown for three individuals after the varying stimuli.

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