Table 3.

BER protein abundance with age

Protein	Models	Ages	Findings	Selected Reference
POLβ	Mouse (C57BL/6)	4–6, 22–26 mo	↓ levels of POLβ protein in nuclear extracts from brain, kidney, liver, spleen and testes	Cabelof et al., 2002
POLβ	Rats (Fisher 344) rats	at age 6 wk, 60% calorie restricted; 4–6, 22–24 mo	CR completely reverses age related decline in POLβ abundance in nuclear extracts from brain, liver and testes	Cabelof et al., 2003
POLβ OGG1	Rats (Sprague Dawley)	17 d embryos, 1, 2, 3 wk 5, 30 mo	Age dependent decrease in protein levels in brain mitochondria.	Chen et al., 2002a
APE1	Mouse (BALB/c)	4, 10, 20 mo	N.C. with age in total liver extracts.	Szczesny and Mitra, 2005
DNA Lig1	Mouse (B6D2F1)	3, 16, 28 mo	N.C. liver or brain or spermatogenic cell nuclear extracts	Intano et al., 2002; Intano et al., 2003
DNA Lig3			N.C. liver or brain or spermatogenic cell nuclear extracts
XRCC1			N.C. liver or brain or spermatogenic cell nuclear extracts
POLβ			↓ in brain; N.C. in liver or spermatogenic nuclear extracts
APE1			↓ in spermatogenic cells nuclear extracts; N.C. in liver or brain
APE1	Mouse (BALB/c)	4, 10, 20 mo	No change total abundance; ↑ nuclear and mitochondrial localization with age in liver	Szczesny and Mitra, 2005
APE1 Ligase 3	Mouse (C57Bl/6)	6 & 18 mo	N.C. in levels with age in various brain regions	Imam et al., 2006

↑ = increase; ↓ = decrease; N.C. = no change.