Table 3.
Protein | Models | Ages | Findings | Selected Reference |
---|---|---|---|---|
POLβ | Mouse (C57BL/6) | 4–6, 22–26 mo | ↓ levels of POLβ protein in nuclear extracts from brain, kidney, liver, spleen and testes | Cabelof et al., 2002 |
POLβ | Rats (Fisher 344) rats | at age 6 wk, 60% calorie restricted; 4–6, 22–24 mo | CR completely reverses age related decline in POLβ abundance in nuclear extracts from brain, liver and testes | Cabelof et al., 2003 |
POLβ OGG1 | Rats (Sprague Dawley) | 17 d embryos, 1, 2, 3 wk 5, 30 mo | Age dependent decrease in protein levels in brain mitochondria. | Chen et al., 2002a |
APE1 | Mouse (BALB/c) | 4, 10, 20 mo | N.C. with age in total liver extracts. | Szczesny and Mitra, 2005 |
DNA Lig1 | Mouse (B6D2F1) | 3, 16, 28 mo | N.C. liver or brain or spermatogenic cell nuclear extracts | Intano et al., 2002; Intano et al., 2003 |
DNA Lig3 | N.C. liver or brain or spermatogenic cell nuclear extracts | |||
XRCC1 | N.C. liver or brain or spermatogenic cell nuclear extracts | |||
POLβ | ↓ in brain; N.C. in liver or spermatogenic nuclear extracts | |||
APE1 | ↓ in spermatogenic cells nuclear extracts; N.C. in liver or brain | |||
APE1 | Mouse (BALB/c) | 4, 10, 20 mo | No change total abundance; ↑ nuclear and mitochondrial localization with age in liver | Szczesny and Mitra, 2005 |
APE1 Ligase 3 | Mouse (C57Bl/6) | 6 & 18 mo | N.C. in levels with age in various brain regions | Imam et al., 2006 |
↑ = increase; ↓ = decrease; N.C. = no change.