Figure 7.

Individual PAWP profiles of nicorandil following administration to acute heart failure patients. Left upper panel: bolus injection of nicorandil at a dose of 4, 8, 12 and 18 mg kg⁻¹. Right upper panel: 6 h or 24 h infusion of nicorandil at a dose of 50, 100, 150, 200 and 250 µg kg⁻¹ h⁻¹ following a bolus injection of nicorandil at a dose of 200 µg kg⁻¹ h⁻¹. Left lower panel: 48 h infusion of nicorandil at a dose of 200 µg kg⁻¹ h⁻¹ following a bolus injection of nicorandil at a dose of 200 µg kg⁻¹