Table 3.

Model building table for nicorandil pharmacodynamics and disease progress

Model	Disease progress	Drug effect	Random effects	Estimation	Obj	Sig
10	Exponential	Emax	Covariance of S0, SS, EC50	Simultaneous	7600.48	5.9
11	Exponential	Emax	Covariance of S0, SS, EC50	Sequential	7601.34	6.5
12	Exponential	Linear	Covariance of S0, SS, EC50	Sequential	7624.16	5.4
13	Exponential	Emax	No covariance	Sequential	7624.92	5.9
14	Linear	Sigmoid Emax	Covariance of S0, alpha, Emax, EC50	Sequential	7634.66	6.6
15	Linear	Emax	Covariance of S0, alpha, Emax, EC50	Sequential	7634.80	6.3
16	Linear	Emax	No covariance	Sequential	7639.33	5.9
17	None	Emax	Covariance of S0, Emax, EC50	Sequential	7664.96	.

Obj, NONMEM objective function value; Sig, NONMEM estimate of minimum number of significant digits in the parameter estimates.