Table 4.

Pharmacodynamic random effects model parameter estimates for the effect of nicorandil on PAWP using model 10. Bootstrap coefficient of variation (standard deviation/median) and empirical 90% confidence interval

Statistic	Description	Median	CV %	Confidence interval
				5%	95%
PPV_S0	Population parameter variability in S0	0.210	8.5	0.180	0.238
PPV_Sss	Population parameter variability in Sss	0.320	23.9	0.233	0.431
PPV_EC50	Population parameter variability in EC50	0.879	58.4	0.075	1.76
BSV_CL	Between subject variability in CL	0.686	19.0	0.523	0.941
BSV_V1	Between subject variability in V1	0.301	26.2	0.214	0.453
BSV_Q	Between subject variability in Q	0.414	82.1	0.067	1.167
BOV_CL1	Between occasion variability in CL	0.199	24.7	0.116	0.279
R12	Correlation of S0 and Sss	0.864	16.1	0.621	1.00
R23	Correlation of Sss and EC50	0.054	692.5	−10.57	0.651
R78	Correlation of CL and V1	0.257	104.0	−0.1673	0.709
R89	Correlation of V1 and Q	0.957	37.0	0.3044	1.00
PPV_RUVFX	Population parameter variability in PAWP residual error	0.308	42.3	0.010	0.487
RUV_SDFX	Standard deviation of PAWP residual error	2.5	6.9	2.22	2.79
PPV_RUVCP	Population parameter variability in nicorandil residual error	0.716	27.3	0.419	1.05
RUV_CVCP	Coefficient of variation of nicorandil residual error	0.212	12.9	0.172	0.260
RUV_SDCP	Standard deviation of nicorandil residual error	6.82	38.0	3.73	12.0