Figure 4.

GABAA and GABAB receptors mediate neurogliaform cells (ngfc) to regular spiking interneuron (rs) connections. (A) Three-dimensional light microscopic reconstructions of the presynaptic neurogliaform cell (black) and the postsynaptic regular spiking interneuron (gray). Axonal (left and right) and dendritic (middle) reconstructions are separated for clarity, the relative position of the two cells is shown by the dendritic arborizations. (B) Firing patterns of the two cells. (C) Single action potentials in the neurogliaform cell elicited slow IPSPs with two components in the regular spiking interneuron. The early component could be blocked by the GABAA receptor blocker gabazine (10 μM) and the late phase of IPSP was abolished by the subsequent addition of CGP35348 (60 μM).