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. 2007 Nov 2;1:1. doi: 10.3389/neuro.04.001.2007

Figure 2.

Figure 2

DA-induced depression of excitatory inputs to SLM interneurons. (A) Intracellular recording from SLM interneurons. Biocytin-filled electrodes were used for the staining of SLM interneurons. The inset shows representative spike activities following current injection. Scale bar = 50 ms, 20 mV. (B) After DA application, the EPSP evoked by the TA pathway stimulation was significantly depressed. p < 0.01 (n = 5). Scale bar = 1 mV, 20 ms. (C) Whole-cell voltage-clamp recordings from CA1 pyramidal neurons at a holding potential of 0 mV. The late component of the IPSC disappeared after excitatory blockade with CNQX (10 μM) and APV (25 μM). The size of late IPSC showed large variability among recorded neurons. Scale bar = 50 pA, 100 ms. (D) The monosynaptic IPSC was blocked by GABA receptor antagonists, bicuculline (10 μM) and CGP 55845A (1 μM). Scale bar = 50 pA, 100 ms. (E) DA did not influence monosynaptic IPSC. Scale bar = 20 pA, 50 ms.