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. 2008 Sep;173(3):892–900. doi: 10.2353/ajpath.2008.080001

Figure 5.

Figure 5

Normal T cell responses in EAE induced WT and VWFKO mice. (A) WT and VWFKO CD4 T cells (n = 6 to 8 mice/strain) have equivalent ex vivo proliferative responses to MOG35–55 10 days following immunization with MOG35–55+CFA+PTX. Mean cpm ± SD were calculated from triplicate wells. (B) Protein production and/or (C) mRNA expression of cytokines/chemokines by MOG35–55 stimulated splenocytes does not differ between WT and VWFKO mice immunized with MOG35–55+CFA+PTX 10 days earlier. Cytokine production was determined by cytometric bead assay and expression levels determined by real-time RT-PCR. Significance of differences between WT and VWFKO CD4 T-cells responses was determined using the Student’s t-test with a P value of 0.05 as the significance threshold.