Fig. 5.

The effect of proteinase inhibitors on the iron-modulated cytotoxicity (A) and adherence (B). Each proteinase inhibitor was added to low-, normal- or high-iron grown E. histolytica trophozoites 5 min prior to cytotoxicity and adherence assay. E64 (0.2 mM); leupeptin (0.2 mM); PMSF, phenyl-methylsulfonyl fluoride (1 mM); pepstatin A (1 µM); aprotinin (3 µM).