Figure 4.

Alignment of the Snl1p and Pom152p sequences. An ALIGN analysis between the FL proteins revealed significant homology (Dayhoff et al., 1983). The center line designates the identical (capital letter) and conserved (:, .) residues. The boxed residues in the Snl1p sequence (16–35) and Pom152p (177–195) note the position of the respective predicted transmembrane segments. Pom152p is predicted to be oriented as a type II integral membrane protein (Wozniak et al., 1994); however, Pom152p topology has not been experimentally determined. Snl1p is positioned with its C-terminal region cytoplasmically exposed (Figure 8B). If the sequence similarity is significant, this suggests a similar, potential type I orientation for Pom152p.