Figure 3.
Stereoview of compound 6 (red) in ternary complex with DNA and Top1. The lactam side chain is pointing into the major groove and potential hydrogen bonds are indicated in yellow. The diagram is programmed for wall-eyed (relaxed) viewing.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.