Table 1.
Spectrum of efficacy of standard (A), and new AEDs (B). The new AEDs are listed in the order of their marketing in the US, following approval by the US Food and Drug Administration
| Partial | 1ary GTC | G myoclonic | G absence | ||
|---|---|---|---|---|---|
| A | Phenytoin | + | + | - | - |
| Carbamazepine | + | + | - | - | |
| Valproate | + | + | + | + | |
| Phenobarbital | + | + | - | - | |
| Primidone | + | + | + | - | |
| Ethosuximide | - | - | - | + | |
| Methsuximide | + | ? | ? | + | |
| Clonazepam | + | + | + | + | |
| B | Felbamate | +b | + | ? | ? |
| Gabapentina | +b | - | - | - | |
| Lamotriginea | +b | +b | ? | +b | |
| Topiramatea | +b | +b | ? | ? | |
| Tiagabine | +b | ? | - | - | |
| Oxcarbazepinea | +b | +? | - | - | |
| Levetiracetama | +* | +b | +b | ? | |
| Zonisamide | +b | + | + | ? | |
| Pregabalin | +b | ? | - | - |
a
New AED with positive initial monotherapy trials.
b
New AED efficacy indication supported by blinded trials.