Table I.
Genotype frequencies of the ADRB2 gene polymorphisms in healthy subjects and patients with Graves disease with or without ophthalmopathy.
| Healthy subjects
n=301 |
GD total
n=300 |
Ophthalmopathy ATA class 0-II
n=192 |
Ophthalmopathy ATA class III-VI
n=108 |
|
|---|---|---|---|---|
| -367T→C | ||||
| TT | 98 (0.35) | 99 (0.42) | 59 (0.40) | 40 (0.47) |
| CT | 128 (0.46) | 103 (0.44) | 69 (0.46) | 34 (0.40) |
| CC | 51 (0.18) | 32 (0.14) | 21 (0.14) | 11 (0.13) |
| 47A→G | ||||
| AA | 39 (0.14) | 49 (0.17) | 29 (0.16) | 20 (0.19) |
| AG | 139 (0.49) | 144 (0.50) | 92 (0.51) | 52 (0.49) |
| GG | 103 (0.37) | 93 (0.33) | 59 (0.33) | 34 (0.32) |
| 79C→G | ||||
| CC | 91 (0.32) | 105 (0.36) | 66 (0.36) | 39 (0.37) |
| CG | 128 (0.46) | 148 (0.51) | 99 (0.54) | 49 (0.47) |
| GG | 62 (0.22) | 36 (0.12)a | 19 (0.10)b | 17 (0.16) |
a
Chi-square test, GG vs CC+GC, χ2=8.57, df =1, p=0.0034, pcorr=0.030.
b
Chi-square test, GG vs CC+GC, χ2=9.85, df=1, p=0.0017, pcorr=0.015.
GD, Graves disease; ATA, American Thyroid Association. Values in parentheses represent proportion of individuals expressed as a percentage.