Table II.
Allelic frequencies of the ADRB2 gene polymorphisms in healthy subjects and patients with Graves disease with or without ophthalmopathy.
| Healthy subjects
n=301 |
GD total
n=300 |
Ophthalmopathy ATA class 0-II
n=192 |
Ophthalmopathy ATA class III-VI
n=108 |
|
|---|---|---|---|---|
| -367T→C | ||||
| T allele | 324 (0.58) | 301 (0.64) | 187 (0.63) | 114 (0.67) |
| C allele | 230 (0.42) | 167 (0.36) | 111 (0.37) | 56 (0.33) |
| 47A→G | ||||
| A allele | 217 (0.39) | 242 (0.42) | 150 (0.42) | 92 (0.43) |
| G allele | 345 (0.61) | 330 (0.58) | 210 (0.58) | 120 (0.57) |
| 79C→G | ||||
| C allele | 310 (0.55) | 358 (0.62) | 231 (0.63) | 127 (0.60) |
| G allele | 252 (0.45) | 220 (0.38)a | 137 (0.37)b | 83 (0.40) |
a
Chi-square test, χ2=5.12, df =1, p=0.024, pcorr=0.14, power 69%.
b
Chi-square test, χ2=4.99, df =1, p=0.026, pcorr=0.16, power 71%.
GD, Graves disease; ATA, American Thyroid Association. Values in parentheses represent proportion of individuals expressed as a percentage.