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RACK1 regulates PLC activity. (A) Total IP production in Jurkat cells transfected with control (CT) or RACK1 siRNA (siRACK1) and stimulated with SDF1α (500 nM) for the indicated times. (B) RACK1 siRNA-transfected Jurkat cells were pretreated in the absence (CT) or presence of PTx (0.2 μg/ml) overnight, 5 μM of U73122 or U73343, or 50 μM of LY294002 for 1 h, and then stimulated with SDF1α for 10 min before the measurement of total IPs. *p < 0.05, significant difference versus basal.
