Figure 3.

Comparison of different CDM family members. (A) Schematic representation of different CDM family members. Indicated proteins from Hs, Homo sapiens; Dm, Drosophila melanogaster; Ce, Caenorhabditis elegans; Sc, S. cerevisiae and Ca, Candida albicans are shown. The DOCKER domain, together with the SH3 (Src Homology 3) domain are indicated. (B) Alignment of the putative DOCKER Homology Region (DHR) of C. albicans Dck1 and Dck2 with different CDM family members. DHR domains, according to Brugnera et al. (Brugnera et al., 2002), from indicated proteins were aligned with C. albicans Dck1 and Dck2. Residues boxed in black and gray are identical and similar in ≥4 sequences, respectively. The black line above the sequence represents the DOCKER domain (Dedicator of cytokinesis; pfam06920, http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml), which is ∼200 amino acids. The sequence of the DCK1 ORF revealed one base change compared with the sequence in the Candida genome database (http://www.candidagenome.org/), which resulted in a Leu at position 1760.