Figure 4.

Greater MAP reactivity varied with lower gray matter volume and greater BOLD activation in two areas of the medial prefrontal cortex, which encompassed BA 32 of the pACC and BA 10 of the medial prefrontal cortex. A, Statistical parametric maps derived from a whole-brain multiple regression analysis (p < 0.005, k = 750 threshold) identifying two pACC clusters where MAP reactivity varied with gray matter volume (determined by optimized VBM) after covariate control for sex and total gray matter volume (left pACC x, y, z MNI coordinates: −4, 58, 23; t₍₂₈₎ = 3.96, p_uncorrected < 0.001, k = 2402; right pACC: 10, 56, 4; t₍₂₈₎ = 4.49, p_uncorrected = 0.001, k = 1825) (supplemental Fig. 3, Table 3, available at www.jneurosci.org as supplemental material). B, MAP reactivity is shown as a function of mean-centered and sex- and total gray matter-adjusted volume values extracted from the peak voxels of the left (L; open circles, dashed line) and right (R; closed circles, solid line) pACC clusters in A. C, Parametric maps from an ROI regression analysis of the VBM-determined pACC clusters identifying areas where greater MAP reactivity varied with greater BOLD activation after covariate control for sex (left pACC: −9, 63, 6; t₍₂₉₎ = 3.32, p_uncorrected = 0.001, p_FWE = 0.027; k = 74; right pACC: 15, 60, 6; t₍₂₉₎ = 2.85, p_uncorrected = 0.004, p_FWE = 0.05, k = 45). D, MAP reactivity is shown as a function of mean-centered and standardized pACC BOLD activation values extracted from the peak voxels of the left (open circles, dashed line) and right (closed circles, solid line) pACC clusters in C. *p < 0.01.