Table 4.
Haplo-type # | KIR 2 | Psoriatis N = 116 (%) | Controls N = 123 (%) | OR | P value* | |||||
DS2 | DL2/3 | DS3/5 | DL1 | DS1 | DS4/1D | |||||
1 | null | 3 | null | 1 | 1 | 1D | 20 (17) | 0 | 52.5 | 0.00018 |
2 | 1 | 2 | 3 | null | 1 | 1D | 11 (9.6) | 0 | 27 | 0.0058 |
3 | null | 3 | 3 | null | null | 1D | 6 (5.3) | 2 (1.5) | 2.9 | NS |
4 | null | 3 | 5 | 1 | 1 | null | 6 (5.2) | 7 (5.6) | 0.9 | NS |
5 | null | 3 | 3 | 1 | null | 1D | 15 (13) | 30 (24) | 0.5 | NS |
6 | 1 | 2 | 5 | null | 1 | null | 3 (2.5) | 7 (6.4) | 0.5 | NS |
7 | null | 3 | null | 1 | null | 1D | 0 | 16 (13) | 0.03 | 0.00018 |
8 | 1 | 2 | - | null | 1 | 1D | 17 (15) | 0 | 43.4 | 0.00018 |
9 | null | 3 | - | 1 | 1 | 1D | 16 (14) | 0 | 40.6 | 0.00018 |
10 | null | 3 | - | 1 | 1 | DS4 | 6 (5.3) | 0 | 14.5 | NS |
11 | 1 | 2 | - | 1 | null | 1D | 7 (6) | 3 (2.3) | 2.4 | NS |
12 | null | 3 | - | 1 | 1 | null | 19 (16) | 14 (11) | 1.6 | NS |
13 | null | 3 | - | null | null | 1D | 6 (5) | 7 (5.7) | 0.9 | NS |
14 | null | 3 | - | 1 | null | 1D | 19 (16) | 44 (36) | 0.4 | NS |
15 | 1 | 2 | - | null | null | DS4 | 3 (2.4) | 8 (6.6) | 0.4 | NS |
16 | 1 | 2 | - | null | null | 1D | 0 | 7 (5.6) | 0.07 | NS |
17 | 1 | 2 | - | 1 | 1 | null | 0 | 7 (5.6) | 0.07 | NS |
18 | null | 3 | - | 1 | null | DS4 | 0 | 7 (5.6) | 0.07 | NS |
*with Bonferroni correction (correction factor = 18)
The distribution of KIR haplotypes among psoriasis patients and controls obtained with NullHap based on genotypes reported by Luszczek et al. [16]. Only haplotypes with frequency > 5% in either group are shown. Odds ratio (OR) calculated according to Haldane [22], P value calculated by Fisher exact test. NS -not significant.