Table 2.

Day 28 failure rates estimated by four methods – AS+AQ treatment

		Day 28 failure rates % [CI95%]
Year	Country & Site	Method 1a (per protocol)	Method 1b	Method 2a (WHO 2001)	Method 2b
2003	Angola, Kuito	1.3	1.2	1.2	1.2
		[0–6.8]	[0–6.4]	[0.2–8.3]	[0.2–8.1]
2003	DRC, Boende	18.3	14.1	15.3	56.3
		[9.5–30.4]	[7.2–23.8]	[8.7–25.9]	[45.8–67.4]
2003	S Sudan, Nuba	7.3	5.6	6.2	8.4
		[2.0–17.6]	[1.5–12.6]	[2.4–15.7]	[3.9–18.0]
2003	Uganda, Amudat	22.6	8.8	10.4	21.4
		[9.6–41.1]	[3.6–17.2]	[4.9–21.1]	[14.0–31.8]
2003	Uganda, Jinja	7.9	6.5	7.0	12.2
		[3.2–15.7]	[2.7–13.0]	[3.4–14.1]	[7.2–20.1]
2003	Uganda, Kampala	4.9	4.1	4.3	4.3
		[1.0–13.7]	[0.9–11.5]	[1.4–12.8]	[1.4–12.9]
2004	Angola, Caala	0	0	0	1.5
		[0–6.0]*	[0–5.7]*	[0–5.8]*	[0.2–10.4]
2004	Congo, Kindamba	6.0	4.8	4.8	6.4
		[1.6–14.6]	[1.3–11.9]	[1.8–12.2]	[2.9–13.7]
2004	DRC, Kabalo	0	0	0	4.4
		[0–8.4]*	[0–7.9]*	[0–7.9]*	[1.1–16.3]
2004	Guinea, Dabola	1.0	0.9	0.9	0.9
		[0–5.3]	[0–5.1]	[0.1–6.5]	[0.1–6.5]
2004	S Leone, Kailahun	27.0	15.4	19.0	20.5
		[16.6–39.6]	[9.3–23.6]	[12.3–28.8]	[13.5–30.5]
2004	Uganda, Apac	24.5	15.0	15.7	15.9
		[16.2–34.4]	[9.8–21.7]	[10.7–22.7]	[10.8–23.1]
2004	Uganda, Arua	28.7	19.9	20.0	20.0
		[20.4–38.2]	[13.9–27.0]	[14.5–27.2]	[14.6–27.0]
2004	Uganda, Tororo	39.3	14.5	17.8	20.0
		[27.1–52.7]	[9.5–20.9]	[12.1–25.8]	[13.6–28.9]
2005	Uganda, Tororo	13.9	5.5	5.4	5.9
		[6.9–24.1]	[2.6–9.8]	[2.9–9.8]	[3.3–10.4]

*one-sided 97.5% CIs