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. 2008 May 28;100(2):690–697. doi: 10.1152/jn.90378.2008

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FIG. 1. — Changes in miniature excitatory postsynaptic current (mEPSC) amplitudes and frequency in neuronal cultures during development. A: mEPSC amplitudes did not change significantly during the period between 14 and 25 days in vitro (DIV). In contrast, mEPSC frequency steadily increased until ∼18 DIV. After 18 DIV, the increase in mEPSC frequency accelerated. Unless otherwise noted, all recordings in this study were obtained in cultures at 21–22 DIV (). , raw data; ○, the average mEPSC amplitudes; •, the average mEPSC frequency. B: an example of membrane current recordings used for mEPSC analysis. C: averaged mEPSC (obtained from 97 individual mEPSCs) of a representative recording.

Inline graphic — Changes in miniature excitatory postsynaptic current (mEPSC) amplitudes and frequency in neuronal cultures during development. A: mEPSC amplitudes did not change significantly during the period between 14 and 25 days in vitro (DIV). In contrast, mEPSC frequency steadily increased until ∼18 DIV. After 18 DIV, the increase in mEPSC frequency accelerated. Unless otherwise noted, all recordings in this study were obtained in cultures at 21–22 DIV (). , raw data; ○, the average mEPSC amplitudes; •, the average mEPSC frequency. B: an example of membrane current recordings used for mEPSC analysis. C: averaged mEPSC (obtained from 97 individual mEPSCs) of a representative recording.